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Publications by Michael P. Lisanti

Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Pestell, R.G., Tanowitz, H.B., Sotgia, F., Lisanti, M.P. (2011). Stromal-Epithelial Metabolic Coupling in Cancer: Integrating Autophagy and Metabolism in the Tumor Microenvironment. Int J Biochem Cell Biol. February 5, In Press. Pavlides, S., Gutierrez-Pajares, L.J., Danilo, C., Lisanti, M.P., Frank. P.G. (2011). Atherosclerosis, Caveolae, and Caveolin-1. Publishers Landes Biosciences. From the book Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms Casey, T., Sotgia, F., Whitaker-Menezes, D., Balliet, R., Eaton, G., Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Iozzo, R., Pestell, R.G., Scherer, P.E., Capozza, F., and M.P. Lisanti. (2011). Caveolin-1 and Mitochondrial SOD2 (MnSOD) Function as Tumor Suppressors in the Stromal Microenvironment: A New Genetically Tractable Model for Human Cancer Associated Fibroblasts. Cancer Biology and Therapy, 11 (4):383-394. Martinez-Outschoorn, U.E., Trimmer, C., Lin, Z., Whitaker-Menezes , D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Martinez-Cantarin, M.P., Capozza, F., Witkiewicz, A.K., Flomenberg, N., Howell, A., Pestell, R.G., Caro, J., Lisanti, M.P., and Sotgia, F. (2010). Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NF?B activation in the tumor stromal microenvironment. Cell Cycle, 9 (17):3515-3533. Chiavarina, B., Whitaker-Menezes, D., Migneco, G., Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Tanowitz, H.B., Casimiro, M.C., Wang, C., Pestell, R.G., Grieshaber, P., Caro, J., Sotgia, F., and Lisanti, M.P. (2010). HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle, 9 (17):3534-3551. Bonuccelli, G., Tsirigos, A., Whitaker-Menezes, D., Pavlides, S., Pestell, R.G., Chiavarina, B., Frank, P.G., Flomenberg, N., Howell, A., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti., M.P. (2010). Ketones and lactate “fuel” tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle, 9 (17):3506-3514. Lisanti, M.P., Martinez-Outschoorn, U.E., Chiavarina, B., Pavlides, S., Whitaker-Menezes, D., Tsirigos, A., Witkiewicz, A.K., Lin, Z., Balliet, R., Howell, A., and Sotgia, F.. (2010). Understanding the “Lethal” Drivers of Tumor-Stroma Co-Evolution: Emerging Role(s) for Hypoxia, Oxidative Stress, and Autophagy/Mitophagy in the Tumor Micro-Environment. Cancer Biology & Therapy, 15: 10 (6):537-542. Pavlides, S., Tsirigos, A., Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Flomenberg, N., Frank, P.G., Casimiro, M.C., Wang, C., Pestell, R.G., Martinez-Outschoorn, U.E., Howell, A., Sotgia, F., and Lisanti., M.P. (2010). The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle, 9 (17):3485-3505. Martinez-Outschoorn, U.E., Balliet, R., Rivadeneira, D., Chiavarina, B., Pavlides, S., Wang, C., Whitaker-Menezes, D., Daumer, K.M., Lin, Z., Witkiewicz, A.K., Flomenberg, N., Howell, A., Pestell, R.G., Knudsen, E., Sotgia, F. and Lisanti, M.P. (2010). Oxidative stress in cancer fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle, 9 (16):3256-3276. Martinez-Outschoorn, U.E., Pavlides, S., Whitaker-Menezes, D., Daumer, K.M., Milliman, J.N., Chiavarina, B., Migneco, G., Witkiewicz, A.K., Martinez-Cantarin, M.P., Flomenberg, N., Howell, A., Pestell, R.G., Lisanti, M.P. and Sotgia, F. (2010). Tumor Cells Induce the Cancer Associated Fibroblast Phenotype Via Caveolin-1 Degradation: Implications for Breast Cancer and DCIS Therapy with Chloroquine. Cell Cycle, 9 (12):2423-2433. Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Castello-Cros, R., Pavlides, S., Pestell, R.G., Fatatis, A., Flomenberg, N., Tsirigos, A., Martinez-Outschoorn, U.E., Howell, A., Sotgia, F. and Lisanti, M.P. (2010). Glycolytic Cancer Associated Fibroblasts Promote Breast Cancer Tumor Growth, without a Measurable Increase in Angiogenesis: Evidence for Stromal-Epithelial Metabolic Coupling. Cell Cycle, 9 (12):2412-2422. Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P.G., Casimiro, M.C., Wang, C., Fortina, P., Addya, S., Pestell, R.G., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti., M.P. (2010). Loss of Stromal Caveolin-1 Leads to Oxidative Stress, Mimics Hypoxia, and Drives Inflammation in the Tumor Microenvironment, Conferring the “Reverse Warburg Effect”. A Transcriptional Informatics Analysis with Validation”. Cell Cycle, 9 (11):2201-2219. Bonuccelli, G., Whitaker-Menezes, D., Castello-Cros, R., Pavlides, S., Pestell, R.G., Fatatis, A., Witkiewicz, A.K., Vander Heiden, M.G., Migneco, G., Chiavarina, B., Frank, P.G., Capozza, F., Flomenberg, N., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti., M.P. (2010). The Reverse Warburg Effect: Glycolysis Inhibitors Prevent the Tumor Promoting Effects of Caveolin-1 Deficient Cancer Associated Fibroblasts”. Cell Cycle, 9 (10):1960-1971. Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P.G., Pestell, R.G., Martinez-Outschoorn, U.E., Howell, A., Sotgia, F., and Lisanti, M.P. (2010). Transcriptional Evidence for the “Reverse Warburg Effect” in Human Breast Cancer Stroma: Similarities with Alzheimer’s Disease Brain. Aging, 2 (4):185-199. Martinez-Outschoorn, U.E., Whitaker-Menezes , D., Pavlides, S., Chiavarina, B., Bonuccelli, G., Trimmer, C., Tsirigos, A. Migneco, G., Witkiewicz, A.K., Balliet, R., Mercier, I., Wang, C., Flomenberg, N., Howell, A., Lin, Z., Caro, J., Pestell, R.G., Sotgia, F. and Lisanti, M.P. (2010). The “Autophagic Tumor Stroma Model of Cancer Cell Metabolism” or “Battery-Operated Tumor Growth”: A Simple Solution to the Autophagy Paradox.. Cell Cycle, 1: 9 (21). Witkiewicz, A.K., Freydin , B., Chervoneva , I., Potoczek , M., Rizzo , W., Rui, H., Brody, J.R., Schwartz, G.F., Lisanti , M.P. 2010. Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence. Cancer Biology and Therapy., 10: 391-396. Witkiewicz, A.K., Dasgupta, A., Sammons, S., Er, O., Potoczek , M.B., Guiles, F., Sotgia, F., Brody, J.R., Mitchell, E.P., and M.P. Lisanti. 2010. Loss of Stromal Caveolin-1 Expression Predicts Poor Clinical Outcome in Triple Negative and Basal-Like Breast Cancers. Cancer Biology and Therapy., 10: 135-143. Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A.K., Frank, P.G., Casimiro, M.C., Wang, C., Fortina, P., Addya, S., Pestell, R.G., Martinez-Outschoorn, U.E., Sotgia, F., and Lisanti, M.P. (2009). The Reverse Warburg Effect: Aerobic Glycolysis in Cancer Associated Fibroblasts and the Tumor Stroma. Cell Cycle, 8: (23) 3984-4001. Jasmin, J.F., Yang, M., Iacovitti, L., and M. P. Lisanti. 2009. Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain. Cell Cycle., 8: 3978-3983. Frank, P.G., Pavlides, S., and M.P. Lisanti. (2009). Caveolae and Transcytosis in Endothelial Cells: Role in Atherosclerosis. Cell Tissue Res. 335: 41-7. Mercier, I., Jasmin, J-F., Pavlides, S., Minetti, C., Pestell, R.G., Frank, P.G., Sotgia, F., and M.P. Lisanti. (2009). Clinical and Translational Implications of the Caveolin Gene Family: Lessons from Mouse Models and Human Genetic Disorders. Lab Invest, 89:614-23. Felicetti, F., Parolini, I., Bottero, L., Fecchi, K., Errico, M.C., Raggi, C., Biffoni, M., Spadaro, F., and Lisanti, M.P., Sargiacomo M., Carè A. 2009. Caveolin-1 tumor-promoting role in human melanoma. Int J Cancer. 125: 1514-22. Di Vizio, D., Morello, M., Sotgia, F., Pestell, R.G., Freeman, M.R., and M.P. Lisanti. 2009. An Absence of Stromal Caveolin-1 is Associated with Advanced Prostate Cancer, Metastatic Disease Spread, and Epithelial Akt Activation. Cell Cycle, 8: 2420-4. Witkiewicz, A.K., Dasgupta, A., Nguyen, K.H., Liu, C., Kovatich, A.J., Schwartz, G.F., Pestell, R.G., Sotgia, F., Rui, H., and M.P. Lisanti. 2009. Stromal Caveolin-1 Levels Predict Early DCIS Progression to Invasive Breast Cancer. Cancer Biology & Therapy, 8: 1073-81. Witkiewicz, A.K., Dasgupta, A., Sotgia, F., Mercier, I., Pestell, R.G., Sabel, M., Kleer, C.G., Brody, J.R., and M.P. Lisanti. 2009. An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers. Am. J. Pathol., 174: 2023-34. Mercier, I., Bryant, K.G., Sotgia, F., Bonuccelli, G., Witkiewicz, A.K., Dasgupta, A., Jasmin, J.-F., Pestell, R.G., and M.P. Lisanti. 2009. Using Caveolin-1 Epithelial Immunostaining Patterns to Stratify Human Breast Cancer Patients and Predict the Caveolin-1 (P132L) Mutation. Cell Cycle, 8: 1396-401. Bonuccelli, G., Casimiro, M.C., Sotgia, F., Wang, C., Liu, M., Katiyar, S., Zhou, J., Dew, E., Capozza, F., Daumer, K., Minetti, C., Alpy, F., Rio, M.-C., Tomasetto, C., Mercier, I., Frank, P.G., Pestell, R.G., and M.P. Lisanti. 2009. Caveolin-1 (P132L), A Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature. Am. J. Pathol., 174: 1650-62. Mercier, I., Casimiro, M.C., Zhou, J., Wang, C., Plymire, C., Bryant, K.G., Daumer, K.M., Sotgia, F., Bonuccelli, G., Witkiewicz, A.K., Jasmin, J.-F., Lin, J., Tran, T.H., Rui, H., Pestell, R.G., and M.P. Lisanti. 2009. Genetic Ablation of Caveolin-1 Drives Estrogen-Hypersensitivity and the Development of DCIS-like Mammary Lesions. Am. J. Pathol., 174: 1172-1190. Sotgia, F., Del Galdo, F., Casimiro, M.C., Bonuccelli, G. Mercier, I., Whitaker-Menezes, D., Daumer, K.M., Zhou, J., Wang, C., Katiyar, S., Xu, H., Bosco, E., Quong, A.A., Aronow, B., Witkiewicz, A.K, Minetti, C., Frank, P.G., Jimenez, S.A., Knudsen, E.S., Pestell, R.G., and M.P. Lisanti. 2009. Caveolin-1 (-/-) Null Mammary Stromal Fibroblasts Share Characteristics with Human Breast Cancer-Associated Fibroblasts. Am. J. Pathol., 174: 746-61. Sotgia, F., Casimiro, M.C., Bonnucelli, G., Liu, M., Menezes, D., Er, O., Daumer, K., Mercier, I., Witkiewicz, A.K., Minetti, C., Capozza, F., Rui, H., Frank, P.G., Millimam, J., Knudsen, E.S., Zhou, J., Wang, C., Pestell, R.G., and M.P. Lisanti. 2009. Loss of Caveolin-3 Induces a Lactogenic Microenvironment that is Protective Against Mammary Tumor Formation. Am. J. Pathol., 174: 613-29. Marmon, S., Hinchey, J., Oh, P., Cammer, M., de Almeida, C.J., Gunther, L., Raine, C.S., and M.P. Lisanti. 2009. Caveolin-1 Expression Determines the Route of Neutrophil Extravasation through Skin Microvasculature . Am. J. Pathol., 174: 684-92. Marmon, S., Hinchey, J., Raine, C.S., and M.P. Lisanti. 2009. Chemokine Transport and Leukocyte Extravasation Through Dermal Microvasculature in the Absence of Caveolae. J. Dermatol. Sci., 53: 225-8. Marmon, S., Cammer, M., Raine, C.S., and M.P. Lisanti. 2009. Transcellular Migration of Neutrophils is a Quantitively Significant Pathway Across Dermal Microvascular Endothelial Cells. Exper. Dermatol., 18: 88-90. Witkiewicz, A.K., Nguyen, K.H., Dasgupta, A., Kennedy, E.P., Yeo, C.J., Lisanti, M.P., and J.R. Brody. 2008. Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: Implications for tumor progression and clinical outcome. Cell Cycle. 7: 3021-5. Nagajyothi, F., Desruisseaux, M.S., Thiruvur, N., Weiss, L.M., Braunstein, V.L., Albanese, C., Teixeira, M.M., de Almeida, C.J., Lisanti, M.P., Scherer, P.E., and H.B. Tanowitz. 2008. Trypanosoma cruzi Infection of Cultured Adipocytes Results in an Inflammatory Phenotype. Obesity (Silver Spring), 16: 1992-7. Mercier, I., Casimiro, M.C., Wang, C., Rosenberg, A.L., Quong, J., Allen, K.G., Danilo, C., Sotgia, F., Bonnucelli , G., Jasmin , J.F., Xu, H., Bosco, E., Aronow, B., Witkiewicz, A., Pestell , R.G., Knudsen , E.S., and M.P. Lisanti . 2008. Human Breast Cancer-Associated Fibroblasts (CAFs) Show Caveolin-1 Down-regulation and RB Tumor Suppressor Functional Inactivation: Implications for the Response to Hormonal Therapy. Cancer Biology & Therapy, 7: 1212-1225. Abdulghani, J., Gu, L., Dagvadorj, A., Lutz, J., Leiby, B., Bonucelli, G., Lisanti, M.P., Zellweger, T., Alanen, K., Mirtti, T., Visakorpi, T., Bubendorf, L., Nevalainen, M.T. 2008. Stat3 Promotes Metastatic Progression of Prostate Cancer. Am J Pathol., 172: 1717-28. Frank, P.G., Pavlides, S., Cheung, W.C., Daumer, K., and M.P. Lisanti. (2008). Role of Caveolin-1 in the Regulation of Lipoprotein Metabolism. Am. J. Physiol. (Cell Physiol.), 295: C242-8. Wu, K., Katiyar, S., Li, A., Liu, M., Ju, X., Popov, V.M., Jiao, X., Lisanti, M.P., Casola, A., Pestell, R.G. 2008. Dachshund (DACH1) inhibits Oncogene-induced breast cancer cellular migration and invasion through suppression of Interleukin-8. Proc. Natl. Acad. Sci., USA, 105: 6924-9. Assereto, S., Mastrototaro, M., Stringara, S., Gazzerro, E., Broda, P., Nicchia, G.P., Svelto, M., Bruno, C., Nigro, V., Lisanti, M.P., Frigeri , A., and C. Minetti. 2008. Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies. Cell Cycle. 7: 2199-207. Del Galdo, F., Sotgia, F., de Almeida, C., Jasmin, J.F., Musick, M., Lisanti, M.P., and Jimenez, S.A. 2008. Decreased expression of Caveolin-1 in Systemic Sclerosis: Crucial role in the pathogenesis of tissue fibrosis. Arthritis & Rheumatism, 58: 2854-65. Di Vizio, D., Adam, R.M., Kim, J., Kim, R., Sotgia, F., Williams, T., Demichelis, F., Solomon, K.R., Loda, M., Rubin, M.A., Lisanti, M.P., and M.R. Freeman . 2008. Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle. 7: 2257-67. Augustus, A.S., Buchanan, J., Addya, S., Giuseppe, R., Pestell, R.G., Fortina, P., Koch, W.J., Bensadoun, A., Abel, E.D., and M.P. Lisanti. 2008. Substrate Uptake and Metabolism are Preserved in Hypertrophic Caveolin-3 Knockout Hearts. Am. J. Physiol. (Heart and Circ. Physiol.), 295: H657-66. Augustus, A.S., Buchanan, J., Gutman, E., Giuseppe, R., Pestell, R.G., Fortina, P., Koch, W.J., Bensadoun, A., Abel, E.D., and M.P. Lisanti. 2008. Hearts Lacking Caveolin-1 Develop Hypertrophy with Normal Cardiac Substrate Metabolism. Cell Cycle, 7: 2509-18. Chen, J., Capozza, F., Wu, A., Deangelis, T., Sun, H., Lisanti, M.P., Baserga, R. 2008. Regulation of insulin receptor substrate-1 expression levels by caveolin-1. J Cell Physiol., 217: 281-9. Mercier, I., Vuolo, M., Jasmin, J.F., Medina, C.M., Williams, M., Mariadason, J.M., Qian, H., Xue, X., Pestell, R.G., Lisanti, M.P., and Kitsis, R.N. 2008. ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer. Cell Cycle, 7:1640-7. Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P. Groth, D. F., Yehiely, F., Korth, C., Moore, R. C., Tatzelt, J., Rubenstein, E., Boucheix, C., Yang, X., Stanley, P., Lisanti, M. P., Dwek, R. A., Rudd, P. M., Moskovitz, J., Epstein, C. J., Dawson Cruz, T., Kuziel, W. A., Maeda, N., Sap, J., Hsiao Ashe, K., Carlson, G. A., Tesseur, I., Wyss-Coray, T., Mucke, L., Weisgraber, K. H., Mahley, R. W., Cohen, F. E., and Prusiner, S.B. 2008. Genes contributing to prion pathogenesis. J. Gen. Virol., 89:1777-88. Kim, M, Wu, X., Song, I., Fu, M., Chang, S.H., Lisanti, M.P., and R.G. Pestell. 2008. Selective cytotoxicity of synthesized procyanidin 3-O galloylepicatechin-4b, 8-3-O-galloylcatechin to human cancer cells. Cell Cycle. 7: 1648-57. Traverso, M., Bruno, C., Broccolini, A., Sotgia, F., Donati, M.A., Assereto, S., Gazzerro, E., Lo Monaco, M., Modoni, A., D'Amico, A., Gasperini, S., Ricci, E., Zara, F., Lisanti, M.P., Minetti C. 2008. Truncation of Caveolin-3 causes autosomal-recessive Rippling Muscle Disease. J Neurol Neurosurg Psychiatry. 79:735-7. Jiao, X., Katiyar, S., Liu, M., Mueller, S.C., Lisanti, M.P., Li, A., Pestell, T.G., Wu, K., Ju, X., Li, Z., Wagner, E.F., Takeya, T., Wang, C., Pestell, R.G. 2008. Disruption of c-Jun Reduces Cellular Migration and Invasion through Inhibition of c-Src and Hyperactivation of ROCK II Kinase. Mol Biol Cell., 19: 1378-1390. Rao, M., Casimiro, M.C., Lisanti, M.P., D'Amico, M., Wang, C., Shirley, L.A., Leader, J.E., Liu, M., Stallcup, M., Engel, D.A., Murphy, D.J., Pestell, R.G. 2008. Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle. 7: 647-55. Mukherjee, S., Nagajyothi, F., Mukhopadhyay, A., Machado, F.S., Belbin, T.J., Campos de Carvalho, A., Guan, F., Albanese, C., Jelicks, L.A., Lisanti, M.P., Silva, J.S., Spray, D.C., Weiss, L.M., Tanowitz, H.B. 2008. Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection. Genomics. 91: 423-32. Bianco, C., Strizzi, L., Mancino, M., Watanabe, K., Gonzales, M., Hamada, S., Raafat, A., Sahlah, L., Chang, C., Sotgia, F., Normanno, N., Lisanti, M.P., Salomon, D.S. 2008. Regulation of Cripto-1 Signaling and Biological Activity by Caveolin-1 in Mammary Epithelial Cells. Am J Pathol., 172: 345-57. Traverso, M., Gazzerro, E., Assereto, S., Sotgia, F., Giberti, L., Stringara, S., Pedemonte, M., Biancheri, R., Scapolan, S., Pasquini, E., Donati, M.A., Zara, F., Lisanti, M.P., Bruno, C., and Minetti, C. 2008. Different Phenotypes and Inheritance for Caveolin-3 T78 mutations: Caveolin-3 T78K and T78M missense mutations lead to different phenotypes in vivo and in vitro. Laboratory Investigation., 88: 275-83. Gioiosa, L., Raggi, C., Ricceri, L., Jasmin, J.-F., Frank, P.G., Capozza, F., Lisanti, M.P., Alleva, E., Sargiacomo, M., Laviola, G. 2008. Altered Emotionality, Spacial Memory, and Choliinergic Function in Caveolin-1 Knockout Mice. Behavioural Brain Research., 188: 255-262. Bouzahzah, B., Yurchenko, V., Nagajyothi, F., Hulit, J., Sadofsky, M., Braunstein, V.L., Mukherjee, S., Weiss, H., Machado, F.S., Pestell, R.G., Lisanti, M.P., Tanowitz, H.B., Albanese, C. 2008. Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts. Cell Cycle. 7: 500-3. Biancheri, R., Zara, F., Bruno, C., Rossi, A., Bordo, L., Gazzerro, E., Sotgia, F., Pedemonte, M., Scapolan, S., Bado, M., Uziel, G., Bugiani, M., Doria Lamba, L., Costa, V., Schenone, A., , Rozemuller, A.J., Tortori-Donati, P., Lisanti, M.P., S. van der Knaap, M., and C. Minetti. 2007. Phenotypic characterization of Hypomyelination and Congenital Cataract (HCC). Annals of Neurology, 62: 121-127. Di Vizio, D., Sotgia, F., Williams, T.M., Hassan, G.S., Capozza, F., Frank, P.G., Pestell, R.G., Loda, M., Freeman, M.R., and M.P. Lisanti. 2007. Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression. Cancer Biology & Therapy, 6: 1263-1268. Bonuccelli , G., Sotgia, F., Capozza, F., Gazzerro, E., Minetti, C., and M.P. Lisanti. 2007. Localized treatment with a novel FDA-approved proteasome inhibitor blocks the degradation of dystrophin and dystrophin-associated proteins in mdx mice. Cell Cycle. 6: 1242-8. Ju, X., Katiyar, S., Wang, C. Liu, M., Li, S., Jiao, X., Zhou, J., Turner, J., Lisanti, M.P., Russell, R.G., Mueller, S., Ojeifo, J., Chen, W.S.,Hay, N., Pestell, R.G. 2007. Akt1 governs breast cancer progression in vivo. Proc. Natl. Acad. Sci, USA, 104: 7438-43. Hulit J., Suyama K., Chung S., Keren R., Agiostratidou G., Shan W., Dong X., Williams T.M., Lisanti M.P., Knudsen K., Hazan R.B. 2007. N-Cadherin Signaling Potentiates Mammary Tumor Metastasis via Enhanced Extracellular Signal-Regulated Kinase Activation. Cancer Res., 67: 3106-16. Muehlbauer S.M., Evering T.H., Bonuccelli G., Squires R.C., Ashton A.W., Porcelli S.A., Lisanti M.P., Brojatsch J. 2007. Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle., 6: 758-66. Jasmin, J.F., Malhotra, S., Dhallu, M.S., Mercier, I., Rosenbaum, D.M., and M.P. Lisanti. 2007. Caveolin-1 Deficiency Increases Cerebral Ischemic Injury. Circulation Research., 100: 721-9. Medina, F.A., Cohen, A.W., de Almeida, C.J., Nagajyothi, F., Braunstein, V.L., Teixeira, M.M., Tanowitz, H.B., and M.P. Lisanti. 2007. Immune Dysfunction in Caveolin-1 Null Mice following Infection with Trypanosoma cruzi (Tulahuen Strain). Microbes and Infection, 9: 325-33. Wu, K., Liu, M., Li , A., Donninger, H., Rao, M., Jiao, X., Lisanti, M.P., Cvekl, A., Birrer, M., and R.G. Pestell. 2007. The Cell Fate Determination Factor DACH1 Inhibits c-Jun Induced Contact-Independent Growth. Mol Biol Cell., 18:755-67. Lai, E.W., Rodriguez, O.C., Aventian, M., Cromelin, C., Fricke, S.T., Martiniova, L., Lubensky, I.A., Lisanti, M.P., Picard, K.L., Powers, J.F., Tischler, A.S., Pacak, K., Albanese, C. 2007. ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice. Cell Cycle. 6: 1946-50. Katiyar, S., Jiao, X., Wagner, E., Lisanti, M.P., and R.G. Pestell . 2007. Somatic excision demonstrates c-Jun induces cellular migration and invasion through induction of Stem Cell Factor. Mol Cell Biol., 27: 1356-69. Fang, K., Fu, W., Beardsley, A.R., Sun, X., Lisanti, M.P., and Liu, J. 2007. Overexpression of Caveolin-1 Inhibits Endothelial Cell Proliferation by Arresting the Cell Cycle at G(0)/G(1) Phase. Cell Cycle., 6: 199-204. Schubert, W., Sotgia, F., Cohen, A.W., Capozza, F., Bonuccelli, G., Bruno, C., Minetti, C., Bonilla, E., DiMauro, S., and M.P. Lisanti. 2007. Caveolin-1 (-/-) and Caveolin-2 (-/-) Deficient Mice Both Display Numerous Skeletal Muscle Abnormalities, with Tubular Aggregate Formation . Am. J. Pathology, 170: 316-33. Medina, F.A., de Almeida, C.J., Dew, E., Li, J., Bonuccelli, G., Williams, T.M., Cohen, A.W., Pestell, R.G., Frank, P.G., Tanowitz, H.B., and M.P. Lisanti. 2006. Caveolin-1-Deficient Mice Show Defects in Innate Immunity and Inflammatory Immune Response during Salmonella enterica Serovar Typhimurium Infection. Infection & Immunity, 74: 6665-6674. Li, Z., Jiao, X., Wang, C., Ju, X., Lu, Y., Yuan, L., Lisanti, M.P., Katiyar, S., Pestell , R.G. 2006. Cyclin D1 Induction of Cellular Migration Requires p27KIP1. Cancer Res. 66: 9986-94. Bouzahzah, B., Nagajyothi, F., Desruisseaux, M.S., Krishnamachary, M., Factor, S.M., Cohen, A.W., Lisanti, M.P., Petkova, S.B., Pestell, R.G., Wittner, M., Mukherjee, S., Weiss, L.M., Jelicks, L.A., Albanese, C., Tanowitz, H.B. 2006. Cell Cycle Regulatory Proteins in the Liver in Murine Trypanosoma cruzi Infection. Cell Cycle., 5: 2396-2400. Zara, F., Biancheri, R., Bruno, C., Bordo, L., Assereto, S., Gazzerro, E., Sotgia, F., Wang, X.B., Gianotti, S., Stringara, S., Pedemonte, M., Uziel, G., Rossi, A., Schenone, A., Tortori-Donati, P., van der Knaap, M.S., Lisanti, M.P., and C. Minetti. 2006. Deficiency of Hyccin, a novel membrane protein, causes hypo-myelination and congenital cataract . Nature Genetics, 38:1111-3. Williams, T.M., Sotgia, F., Lee, H., Hassan, G., Di Vizio, D., Bonuccelli, G., Capozza, F., Mercier, I., Rui, H., Pestell, R.G., and M.P. Lisanti. 2006. Stromal and Epithelial Caveolin-1 Both Confer a Protective Effect Against Mammary Hyperplasia and Tumorigenesis: Caveolin-1 Antagonizes Cyclin D1 Function in Mammary Epithelial Cells. Am. J. Pathology, 169: 1784-1801. Hnasko, R., Frank, P.G., Ben-Jonathan, N., and M.P. Lisanti. 2006. PV-1 is negatively regulated by VEGF in the lung of Caveolin-1, but not Caveolin-2, null mice. Cell Cycle, 5: 2012 – 2020. Hnasko, R., Carter, J.M., Medina, F., Frank, P.G., and M.P. Lisanti. 2006. PV-1 labels trans-cellular openings in mouse endothelial cells and is negatively regulated by VEGF. Cell Cycle, 5: 2021 – 2028. Wu, K., Li, A., Rao, M., Liu, M., Dailey, V., Yang, Y., Di Vizio, D., Wang, C., Lisanti, M.P., Sauter, G., Russell, R.G., Cvekl, A., and R.G. Pestell. 2006. DACH1 is a Cell Fate Determination Factor That Inhibits Cyclin D1 and Breast Tumor Growth. Mol. Cell Biol., 26: 7116-29. Jasmin, J.F., Mercier, I., Dupuis, J., Tanowitz, H.B., and M.P. Lisanti. 2006. Short Term Administration of a Cell Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy. Circulation., 114: 912-20. Hulit, J., Lee, R.J., Li, Z., Wang, C., Katiyar, S., Yang, J., Quong, A.A., Wu, K., Albanese, C., Russell, R., Di Vizio, D., Koff, A., Thummala, S., Zhang, H., Harrell, J., Sun, H., Muller, W.J., Inghirami, G., Lisanti, M.P., and P.G. Pestelll. 2006. p27Kip1 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/{beta}-Catenin Signaling. Cancer Res. 66: 8529-41. Frank, P.G., Cheung, M.W., Pavlides, S., Llavaverias, G., Park, D.S., and M.P. Lisanti. 2006. Caveolin-1 and Regulation of Cellular Cholesterol Homeostasis. Am J Physiol (Heart Circ Physiol.), 291: H677-86. Medina, F.A., Williams, T.M., Sotgia, F., Tanowitz, H.B., and M.P. Lisanti. 2006. A Novel Role for Caveolin-1 in B Lymphocyte Function and the Development of Thymus-Independent Immune Responses. Cell Cycle, 5: 1865-1871. Li, T., Sotgia, F., Vuolo, M.A., Li, M., Yang, W.C., Pestell, R.G., Sparano, J.A., and M.P. Lisanti. 2006. Caveolin-1 Mutations in Human Breast Cancer: Functional Association with Estrogen Receptor (ER?lpha) Positive Status, Am. J. Pathol., 168: 1998-2013. Hassan , G.S., Williams, T.M., Frank, P.G., and M.P. Lisanti. 2006. Caveolin-1 Deficient (-/-) Aortic Smooth Muscle Cells Show Cell Autonomous Abnormalities in Proliferation, Migration, and Endothelin-based Signal Transduction. Am. J. Physiol. (Heart and Circ), 290: H2393-401. Khan, E.M., Heidinger, J.M., Levy, M., Lisanti, M.P., Ravid,T., and T. Goldkorn. 2006. EGF receptor exposed to oxidative stress undergoes Src-and caveolin-1-dependent perinuclear trafficking. J. Biol. Chem., 281: 14486-93. Sotgia, F., Schubert, W., Pestell, R.G., and M.P. Lisanti. 2006. Genetic Ablation of Caveolin-1 in Mammary Epithelial Cells Increases Milk Production and Hyper-activates STAT5a Signaling. Cancer Biology & Therapy, 5: 292-297. Assereto, S., Stringara, S., Sotgia, F., Bonuccelli, G., Broccolini, A., Pedemonte, M., Traverso, M., Biancheri, R., Zara, F., Bruno, C., Lisanti, M.P., and C. Minetti. 2006. Pharmacological Rescue of the Dystrophin Complex in Duchenne and Becker Skeletal Muscle Explants by Proteasomal Inhibitor Treatment. Am. J. Phys. (Cell Phys.), 290: C577-C582. Selvaraj ,V., Asano, A., Buttke, D.E., McElwee, J.L., Nelson, J.L., Wolff, C.A., Merdiushev, T., Fornes , M.W., Cohen, A.W., Lisanti , M.P., Rothblat, G.H., Kopf, G.S., and A.J. Travis . 2006. Segregation of micron-scale membrane sub-domains in live murine sperm. J. Cell Physiol. , 206: 636-46. Sotgia, F., Williams, T.M., Schubert, W., Medina, F., Minetti, C., Pestell, R.G., and M.P. Lisanti. 2006. Caveolin-1 Deficiency (-/-) Conveys Premalignant Alterations in Mammary Epithelia, with Abnormal Lumen Formation, Growth Factor Independence, and Cell Invasiveness. Am. J. Pathol., 168: 292-309. Lee, H., Xie, L., Luo, Y., Lee, S.-Y., Lawrence, D.S., Wang, X.B., Sotgia, F., Lisanti, M.P., and Z.-Y. Zhang. 2006. Identification of Phospho-Caveolin-1 as a Novel PTP1B Substrate. Biochemistry, 45: 234-240. Hassan, G., Mukerjee, S., Nagajyothi, Weiss, L.M., Petkova, S.B., de Almeida, C.J.G., Huang, H., Desruisseaux, M.S., Bouzahzah, B., Pestell, R.G., Albanese, C., Christ, G.J., Lisanti, M.P., and H.B. Tanowitz. 2006. Trypanosoma cruzi Infection Induces Proliferation of Vascular Smooth Muscle Cells. Infect. & Immun., 74: 152-9. Sotgia, F., Williams, T.M., Cohen, A.W., Minetti, C., Pestell, R.G., and M.P. Lisanti. 2005. Caveolin-1-Deficient Mice Have An Increased Mammary Stem Cell Population, with Upregulation of Wnt / ?-Catenin Signaling. Cell Cycle., 4: 1808-1816. Li, J., Hassan, G.S., Williams, T.M., Minetti, C., Pestell, R.G., Tanowitz, H.B., Frank, P.G., Sotgia, F., and M.P. Lisanti. 2005. Loss of Caveolin-1 Causes the Hyper-proliferation of Intestinal Crypt Stem Cells, with Increased Sensitivity to Whole Body ?-Radiation. Cell Cycle., 4: 1817-1825. Fine, S.W., Lisanti, M.P., Argani, P., and M. Li. 2005. Caveolin-3 Is a Sensitive and Specific Marker for Rhabdomyosarcoma. Appl. Immunohistochem. Mol . Morphol. 13: 231-236. Li, J., Scherl, A., Medina, F., Frank, P.G., Kitsis, R.N., Tanowitz, H.B., Sotgia, F., and M.P. Lisanti . 2005. Impaired Phagocytosis in Caveolin-1 Deficient Macrophages. Cell Cycle., 4: 1596-1605. Fu, M., Wang, C., Rao, M., Wu, X., Bouras, T., Zhang, X., Li, Z., Jiao, X., Yang, J., Li, A., Perkins, N.D., Thimmapaya, B., Kung, A.L., Munoz, A., Giordano, A., Lisanti, M.P., and R.G. Pestell. 2005. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J . Biol. Chem., 280:29728-42. Wang, C., Fan, S., Li, Z., Fu, M., Rao, M., Ma, Y., Lisanti, M.P., Albanese, C., Katzenellenbogen, B.S., Kushner, P.J., Weber, B., Rosen, E.M., and R.G. Pestell. 2005. Cyclin D1 antagonizes BRCA1 Repression of Estrogen Receptor alpha Activity. Cancer Research, 65: 6557-67. Combs, T.P., Nagajyothi, Mukherjee, S., de Almeida, C.J.G. Jelicks, L.A., Schubert, W., Lin, Y., Jayabalan, D.S., Zhao, D., Braunstein, V.L., Landskroner-Eiger, S., Cordero, A., Factor, S.M., Weiss, L.M., Lisanti, M.P., Tanowitz, H.B., and P.E. Scherer. 2005. The Adipocyte as an Important Target Cell for Trypanosoma cruzi infection. J. Biol. Chem., 280: 24085-94. Williams, T.M., Hassan, G.S., Li, J., Cohen, A.W., Medina, F., Frank, P.G., Pestell, R.G., Di Vizio, D., Loda, M., and M.P. Lisanti. 2005. Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: Genetic Ablation of Cav-1 Delays Advanced Prostate Tumor Development in TRAMP mice. J. Biol. Chem., 280: 25134-25145. Iyengar, P., Espina, V., Williams, T., Lin, Y., Berry, D., Jelicks, L.A., Lee, H., Temple, K., Graves, R., Pollard, J., Chopra, N., Russell, R.G., Sasisekharan, R., Trock, B.J., Lippman, M., Calvert, V.S., Petricoin, E.F., Liotta, L., Dadachova, E., Pestell, R.G., Lisanti, M.P., Bonaldo, P., and P.E. Scherer. 2005. Adipocyte-Derived Collagen VI Affects Early Mammary Tumor Progression in vivo, Demonstrating a Novel Interaction in the Tumor/Stroma Microenvironment. J. Clin. Invest., 115: 1163-1176. Capozza, F., Combs, T.P., Cohen, A.W., Cho, Y.-R., Park, S.-Y., Schubert, W., Williams, T.M., Brasaemle, D.M., Jelicks, L.A., Scherer, P.E., Kim, J.K., and M. P. Lisanti. 2005. Caveolin-3 (-/-) Knockout Mice Show Increased Adiposity and Whole-Body Insulin Resistance, with Ligand-Induced Insulin Receptor Instability in Skeletal Muscle. Am. J. Phys. (Cell Phys.), 288, C1317-C1331. Bonuccelli, G., Sotgia, F., Frank, P.G., Williams, T.M., de Almeida, C.J., Tanowitz, H.B., Scherer, P.E., Hotchkiss, K.A., Terman, B.I., Rollman, B., Alileche, A., Brojatsch, J., and M.P. Lisanti. 2005. Anthrax Toxin Receptor (ATR/TEM8) is Highly Expressed in Epithelial Cells Lining the Toxin’s Three Sites of Entry (Lung, Skin, and Intestine): Implications for the Pathogenesis of Anthrax Infection. Am. J. Phys. (Cell Phys.), 288, C1402-C1410. Hotchkiss, K.A., Basile, C.M., Spring, S.C., Bonuccelli, G., Lisanti, M.P., and B.I. Terman. 2005. TEM8 Expression Stimulates Endothelial Cell Adhesion and Migration By Regulating Cell-Matrix Interactions on Collagen. Experimental Cell Research, 305, 133-44. Cohen, A.W., Schubert, W., Brasaemle, D.L., Scherer, P.E., and M. P. Lisanti. 2005. Caveolin-1 Expression is Essential for Proper Non-shivering Thermogenesis in Brown Adipose Tissue. Diabetes, 54, 679-86. De Souza, A.P., Cohen, A.W., Park, D.S., Woodman, S.E., Tang, B., Gutstein, D.E., Factor, S.M., Tanowitz, H.B., Lisanti, M.P., and Linda A. Jelicks. 2005. MR imaging of caveolin gene-specific alterations in right ventricular wall thickness. Magn. Reson. Imag., 23, 61-8. Capozza, F., Cohen, A.W., Cheung, M.W.C., Sotgia, F., Schubert, W., Battista, M., Lee, H., Frank, P.G., and M.P. Lisanti. 2005. Muscle-Specific Interaction of Caveolin Isoforms (Cav-1, Cav-2, and Cav-3): Differential complex formation between caveolins in fibroblastic versus muscle cells. Am. J. Physiol. (Cell Physiol.), 288, C677-C691. Berg, A.H, Lin, Y., Lisanti, M.P., and P.E. Scherer. 2004. Adipocyte differentiation induces dynamic changes in NFB expression and activity. Am J Physiol (Endocrinol Metab), 287: E1178-88. Williams, T.M., Medina, F., Badano, I., Hazan, R.B., Hutchinson, J., Muller, W.J., Chopra, N.G., Scherer, P.E., Pestell, R.G., and M.P. Lisanti. 2004. Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis In Vivo: Role of Cav-1 in Cell Invasiveness and Matrix Metalloproteinase (MMP-2/9) Secretion. J. Biol. Chem., 279: 51630-46. Wang, X.B., Lee, H., Capozza, F., Marmon, S., Sotgia, F., Brooks, J.W., Campos-Gonzalez, R., and M. P. Lisanti. 2004. Tyrosine Phosphorylation of Caveolin-2 at Residue 27: Differences in the Spacial and Temporal Behavior of Phospho-Cav-2 (pY19 and pY27). Biochemistry, 43: 13694-13706. Subramanian, V., Rothenberg, A., Gomez, C., Cohen, A.W., Garcia, A., Bhattacharyya, S., Shapiro, L., Wang, R., Lisanti, M.P., and D.L. Brasaemle. 2004. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J. Biol. Chem., 279: 42062-71. Mukherjee, S., Huang, H., Petkova, S.B., Albanese, C., Pestell, R.G., Braunstein, V.L., Christ, G.J., Wittner, M., Lisanti, M.P., Berman, J.W., Weiss, L.M., and H.B. Tanowitz. 2004. Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells. Infect Immun. 72, 5274-82. Jasmin, J.-F., Mercier, I., Hnasko, R., Cheung, M.C.-W., Tanowitz, H.B., Dupuis, J., and M.P. Lisanti. 2004. Lung Remodeling and Pulmonary Hypertension after Myocardial Infarction: Pathogenic Role of Reduced Caveolin Expression. Cardiovasc. Res., 63, 747-55. Hassan, G.S., Jasmin, J.-F., Schubert, W., Frank, P.G., and M.P. Lisanti. 2004. Caveolin-1 Deficiency Stimulates Neointima Formation During Vascular Injury. Biochemistry, 43, 8312-8321. Williams, T.M., Lee, H., Cheung, M.W.C., Cohen, A.W., Razani, B., Iyengar, P., Scherer, P.E., Pestell, R.G., and M.P. Lisanti. 2004. Combined Loss of INK4a and Caveolin-1 Synergistically Enhances Cell Proliferation and Oncogene-Induced Tumorigenesis: Role of INK4a/Cav-1 in Mammary Epithelial Cell Hyperplasia. J. Biol. Chem., 279, 24745-24756. Cohen, A.W., Razani, B., Schubert, W., Williams, T.M., Wang, X.B., Iyengar, P., Brasaemle, D.L., Scherer, P.E., and M.P. Lisanti. 2004. Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation. Diabetes, 53, 1261-1270. Frank, P.G., Lee, H., Park, D.S., Tandon, N.N., Scherer, P.E., and M.P. Lisanti. 2004. Genetic Ablation of Caveolin-1 Confers Protection Against Atherosclerosis. Arterio.Thrombo. Vasc. Biol. (ATVB), 24, 98-105. Woodman, S.E., Cheung, M.W.C., Tarr, M., North, A.C., Schubert, W., Lagaud, G., Marks, C.B., Russell, R.G., Factor, S.M., Christ, G.J., and M.P. Lisanti. 2004. Urogenital Alterations in Aged Male Caveolin-1 Knock-out Mice. J. Urology, 171, 950-957. Park, D.S., Cohen, A.W., Frank, P.G., Razani, B., Lee, H., Williams, T.M., Chandra, M., Shirani, J., Pereira de Souza, A., Tang, B., Jelicks, L.A., Factor, S.M., Weiss, L.M., Tanowitz, H.B., and M.P. Lisanti. 2003. Caveolin-1 Null (-/-) Mice Show Dramatic Reductions in Life-span. Biochemistry, 42, 15124-15131. Wu, K., Yang, Y., Davoli, M.A., Wang, C., D'Amico, M., Li, A., Cveklova, K., Kozmik, Z., Russel, R.G., Lisanti, M.P., Cvekl, A., and R.G. Pestell. 2003. DACH1 inhibits TGF? signaling through binding Smad4. J. Biol. Chem., 278, 51673-84. Sotgia, F., Bonuccelli, G., Minetti, C., Woodman, S.E., Capozza, F., Kemp, R.G., Scherer, P.E., and M. P. Lisanti. 2003. Phospho-fructokinase (PFK-M) Requires Caveolin-3 Expression for Plasma Membrane Recruitment and Caveolar Targeting: Implications for the Pathogenesis of Caveolin-related Muscle Diseases. Am. J. Pathol., 163, 2619-2634. Aravamudan, B., Volonte, D., Ramani, R,, Gursoy, E., Lisanti, M.P., London, B., and F. Galbiati. 2003. Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype. Hum Mol Genet. 12, 2777-2788. Sotgia, F., Woodman, S.E., Bonuccelli, G., Capozza, F., Minetti, C., Scherer, P.E., and M. P. Lisanti. 2003. Phenotypic Behavior of Caveolin-3 (R26Q), a Mutant associated with HyperCKemia, Distal Myopathy, and Rippling Muscle Disease. Am. J. Phys. (Cell Phys.), 285, C1150-C1160. Iyengar, P., Combs, T.P., Shah, S.J., Gouon-Evans, V., Pollard, J.W., Albanase, C., Flanagan, L., Tenniswood, M.P., Guha, C., Lisanti, M.P., Pestell, R.G., and P.E. Scherer. 2003. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene, 22, 6408-23. Bonuccelli, G., Sotgia, F., Schubert, W., Park, D.S., Frank, P.G., Woodman, S.E., Insabato, L., Cammer, M., Minetti, C., and and M.P. Lisanti. 2003. Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins. Am. J. Pathol., 163, 1663-1675. Fong, A., Garcia, E., Gwynn, L., Lisanti, M.P., Fazzari, M.J., and M. Li. 2003. Expression of caveolin-1 and 2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Am. J. Clin. Pathol., 120, 93-100. Schubert, W.,Yang, X.Y., Yang, T.T.C., Factor, S.M., Lisanti, M.P., Molkentin, J.D., Rincon, M., and C.-W. Chow. 2003. Requirement of Transcription Factor NFAT in Developing Atrial Myocardium. J. Cell Biol., 161, 861-874. Sotgia, F., Bonuccelli, G., Bedford, M., Brancaccio, A., Mayer, U., Wilson, M.T., Campos-Gonzalez, R., Brooks, J.W., Sudol, M., and M. P. Lisanti. 2003. Localization of phospho-?-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo. Biochemistry, 42, 7110-7123. Cohen, A.W., Razani, B., Wang, X.B., Combs, T.P., Williams, T.M., Scherer, P.E., and M. P. Lisanti. 2003. Caveolin-1 Deficient Mice show Insulin Resistance and Defective Insulin Receptor Protein Expression in Adipose Tissue. Am. J. Phys. (Cell Phys.), 285, C222-C235. Woodman, S.E., Ashton, A.W., Schubert, W., Lee, H., Williams, T., Medina, F.A., Wyckoff, J.B., Combs, T.P., and M.P. Lisanti. 2003. Caveolin-1 Knock-out Mice Show an Impaired Angiogenic Response to Exogenous Stimuli. Am. J. Pathol., 162, 2059-2068. Capozza, F., Williams, T.M., Schubert, W., McClain, S., Bouzahzah, B., Sotgia, F., and M. P. Lisanti. 2003. Absence of caveolin-1 sensitizes mouse skin to carcinogen-Induced epidermal hyperplasia and tumor formation. Am. J. Pathol., 162, 2029-2039. Huang, H., Petkova, S.B., Cohen, A.W., Bouzahzah, B., Chan, J., Zhou, J., Factor, S.M., Weiss, L.M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R.N., Pestell, R.G., Lisanti, M.P., Albanese, C., and H.B. Tanowitz. 2003. Activation of Transcription Factors AP-1 and NF-kappa-B in Murine Chagastic Myocarditis. Infection and Immunity., 71, 2859-67. Williams, T.M., Cheung, M.W.C., Park, D.S., Razani, B., Cohen, A.W., Muller, W.J., Di Vizio, D., Chopra, N.G., Pestell, R.G., and M.P. Lisanti. 2003. Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Molec. Biol. Cell., 14, 1027-1042. Cohen, A.W., ,Park, D.S., Woodman, S.E., Williams, T.M., Chandra, M., Shirani, J., Pereira de Souza, A., Kitsis, R.N., Russell, R.G., Weiss, L.M., Tang, B., Jelicks, L.A., Factor, S.M., Shtutin, V., Tanowitz, H.B., and M.P. Lisanti. 2003. Caveolin-1 null mice develop cardiac hypertrophy with hyper-activation of p42/44 MAP kinase in cardiac fibroblasts. Am. J. Phys. (Cell Phys.), 284, C457-C474. Schubert, W., Frank, P.G., Woodman, S.E., Hyogo, H., Cohen, D.E., Chow, C.-W., and M.P. Lisanti. 2002. Microvascular hyper-permeability in caveolin-1 (-/-) knock-out mice: Treatment with a specific NOS inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 Null Mice. J. Biol. Chem., 277, 40091-40098. Frank, P.G., Marcel, Y.L., Connelly, M.A., Lublin, D.M., Franklin, V., Williams, D.L., and M.P. Lisanti. 2002. Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B, type I (SR-BI). Biochemistry, 41, 11931-11940. Woodman, S.E., Park, D.S., Cohen, A.W., Cheung, M.W.C., Chandra, M., Shirani, J., Tang, B., Jelicks, L.A., Kitsis, R.N., Christ, G.J., Factor, S.M., Tanowitz, H.B., and M.P. Lisanti. 2002. Caveolin-3 Knock-out Mice Develop a Progressive Cardio-myopathy and Show Hyper-activation of the p42/44 MAP kinase cascade. J. Biol. Chem., 277, 38988-38997. Park, D.S., Lee, H., Frank, P.G., Razani, B., Nguyen, A.V., Parlow, A.F., Russell, R.G., Hulit, J., Pestell, R.G., and M.P. Lisanti. 2002. Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyper-activation of the Jak-2/STAT5a signaling cascade. Molec. Biol. Cell., 13, 3416-3430. Lee, H., Park, D.S., Razani, B., Russell, R.G., Pestell, R.G., and M.P. Lisanti. 2002. Caveolin-1 Mutations (P132L and Null) and the Pathogenesis of Breast Cancer : Cav-1 (P132L) behaves in a dominant-negative fashion and Cav-1 (-/-) null mice show mammary epithelial cell hyperplasia. Am. J. Pathology., 161, 1357-1369. Lee, H., Park, D.S., Wang, X.B., Scherer, P.E., Schwartz, P.E., and M.P. Lisanti. 2002. Src-induced Phosphorylation of Caveolin-2 on Tyrosine 19: Phospho-caveolin-2 (pY19) is localized near focal adhesions, remains associated with lipid rafts/ caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J. Biol. Chem., 277, 34556-34567. Volonte', D., Zhang, K., Lisanti, M.P., and F. Galbiati. 2002. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts: Stress-induced premature senescence upregulates the expression of endogenous caveolin-1. Mol. Biol. Cell., 13, 2502-2517. Merlini, L., Carbone, I., Capanni, C., Sabatelli, P., Tortorelli, S., Sotgia, F., Lisanti, M.P., Bruno, C., and C. Minetti. 2002. Familial isolated hyerCKemia associated with a new mutation in the caveolin-3 (CAV-3) gene. J. Neurol. Neurosurg. & Psych., 73, 65-67. Razani, B., Park, D.S., Miyanaga, Y., Ghatpande, A., Cohen, J., Wang, X.B., Scherer, P.E., Evans, T., and M.P. Lisanti. 2002. Molecular cloning and develop-mental expression of the caveolin gene family in the amphibian Xenopus laevis. Biochemistry, 41, 7914-7924. Park, D.S., Woodman, S.E., Schubert, W., Cohen, A.W., Frank, P.G., Chandra, M., Shirani, J., Razani, B., Tang, B., Jelicks, L.A., Factor, S.M., Weiss, L.M., Tanowitz, H.B., and M.P. Lisanti. 2002. Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype. Am. J. Pathology., 160, 2207-2217. Schubert, A.L., Schubert, W., Spray, D.C., and M.P. Lisanti. 2002. Connexin family members target to lipid raft domains and interact with caveolin-1. Biochemistry, 41, 5754-64 Sotgia, F., Razani, B., Bonuccelli, G., Schubert, W., Battista, M., Lee, H., Capozza, F., Schubert, A.L., Minetti, C., Buckley, J.T., and M. P. Lisanti. 2002. Intracellular Retention of GPI-linked Proteins in Caveolin-deficient Cells. Molec. Cell. Biol., 22, 3905-3926. Woodman, S.E., Schlegel, A., Cohen, A.W., and M.P. Lisanti. 2002. Mutational analysis identifies a short atypical membrane attachment sequence (KYWFYR) within caveolin-1. Biochemistry, 41, 3790-3795. Liu, J., Wang, X.B., Park, D.S., and M.P. Lisanti. 2002. Caveolin-1 expression enhances endothelial capillary tubule formation. J. Biol. Chem., 277, 10661-10668. Razani, B., Wang, X.B., Engelman, J.A., Battista, M., Lagaud, G., Zhang, X.L., Kneitz, B., Hou, H., Christ, G.H., Edelmann, W., and M.P. Lisanti. 2002. Caveolin-2 deficient mice show evidence of severe pulmonary dysfunction, without disruption of caveolae formation. Molec. Cell. Biol., 22, 2329-2344. Razani, B. Combs, T.P., Wang, X.B., Frank, P.G., Park, D.S., Russell, R.G., Li, M., Tang, B., Jelicks, L.A., Scherer, PE., and M.P. Lisanti. 2002. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J. Biol. Chem., 277, 8635-8647. Minetti, C., Bado, M., Broda, P., Sotgia, F., Bruno, C., Galbiati, F., Volonte, D., Lucania, G., Pavan, A., Bonilla, E., Lisanti, M.P., and G. Cordone. 2002. Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency. Am. J. Pathology, 160, 265-270. Schubert, W., Frank, P.G., Razani, B., Park, D., Chow, C.-W. and M.P. Lisanti. 2001. Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J. Biol. Chem. (Accelerated Publication), 276, 48619-48622. Bouzahzah, B., Albanese, C., Ahmed, F., Pixley, F., Lisanti, M.P., Segall, J.D., Condeelis, J., Joyce, D., Minden, A., Der, C.J., Chan, A. Symons, M., and R.G. Pestell. 2001. Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Molecular Medicine, 7, 816-830. Sotgia, F., Lee, H., Bedford, M.T., Petrucci, T., Sudol, M., and M.P. Lisanti. 2001. Tyrosine phosphorylation of ?-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry, 40, 14585-14592. Park, D.S., Lee, H., Riedel, C., Hulit, J., Scherer, P.E., Pestell, R.G., and M. P. Lisanti. 2001. Prolactin negatively regulates caveolin-1 gene expression in the mammary gland during lactation, via a Ras-dependent mechanism. J. Biol. Chem., 276, 48389-48397. Razani, B., Engelman, J.A., Wang, X.B., Schubert, W., Zhang, X.L., Marks, C.B., Macaluso, F., Russell, R.G., Li, M., Pestell, R.G., Di Vizio, D., Hou, H., Kneitz, B.,Lagaud, G., Christ, G.J., Edelmann, W., and M. P. Lisanti. 2001. Caveolin-1 null mice are viable but show evidence of hyper-proliferative and vascular abnormalities. J. Biol. Chem., 276, 38121-38138. Frank, P.G., Pedraza, A., Cohen, D.E., and M.P. Lisanti. 2001. Adenovirus-mediated expression of caveolin-1 in mouse liver increases plasma HDL-levels. Biochemistry, 40, 10892-10900. Razani, B., and M.P. Lisanti. 2001. Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am. J. Physiol., 281, C1241-C1250. Schlegel, A., Wang, C., Pestell, R.G., and M.P. Lisanti. 2001. Ligand-independent activation of ER? by caveolin-1. Biochem. J., 359, 203-210. Lee, H., Woodman, S.E., Engelman, J.A., Volonte', D., Galbiati, F., Kaufman, H., Lublin, D.M., and M.P. Lisanti. 2001. Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: Targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin (Y14). J. Biol. Chem., 276, 35150-35158. Galbiati, F., Volonte’, D., Liu, J., Capozza, F., Frank, F.G., Zhu, L., Pestell, R.G., and M.P. Lisanti. 2001. Caveolin-1 expression negatively regulates cell cycle progression by inducing G0/G1 arrest via a p53/p21WAF1/Cip1-dependent mechanism. Molec. Biol. Cell., 12, 2229-2244. Razani, B., Schlegel, A., Liu, J., and M. P. Lisanti. 2001. Caveolin-1, a putative tumour suppressor gene. Biochem. Soc. Trans., 29, 494-499. Galbiati, F., Engelman, J.A., Volonte', D., Zhang, X.L., Minetti, C., Li, M., Hou, H., Kneitz, B., Edelmann, W., and M.P. Lisanti. 2001. Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities. J. Biol. Chem., 276, 21425-21433. Wang, C., Fu, M., Angeletti, R.H., Siconolfi-Baez, L., Reutens, A.T., Albanese, C., Lisanti, M.P., Katzenellenbogen, B.S., Kato, S., Hopp, T., Fuqua, S.A., Kushner, P.J., and R.G. Pestell. 2001. Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. J. Biol. Chem., 276, 18375-18383. Park, D.S., Razani, B., Lasorella, A., Schreiber-Agus, N., Pestell, R.G., Iavarone, A., and M.P. Lisanti. 2001. Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism. Biochemistry, 40, 3354-3362. Frank, P. G., Galbiati, F., Volonte', D., Razani, B., Cohen, D.E., Marcel, Y.L., and M.P. Lisanti. 2001. Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins (HDLs). Am. J. Physiol., 280, C1204-C1214. Wang, C., Fu, M., D'Amico, M., Albanese, C., Brownlee, M., Lisanti, M.P., Chatterjee, K., Lazar, M.A., and R.G. Pestell. 2001. Inhibition of cellular proliferation through IkB kinase-independent and PPARgamma-receptor dependent repression of cyclin D1. Molec. Cell. Biol., 21, 3057-3070. Fine, S., Lisanti, M.P., Galbiati, F., and M. Li. 2001. Elevated expression of caveolin-1 in adenocarcinoma of the colon. Am. J. Clin. Pathol. 115: 719-724. Volonte', D., Galbiati, F., Pestell, R.G., and M.P. Lisanti. 2001. Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Y14) via activation of p38 mitogen-activated protein (MAP) kinase and c-Src kinase: Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. J. Biol. Chem., 276, 8094-8103. Razani, B., Zhang, X.L., Bitzer, M., von Gersdorff, G., Bottinger, E.P., and M. P. Lisanti. 2001. Caveolin-1 regulates TGF-?/ SMAD signaling through an interaction with the TGF-? type I receptor. J. Biol. Chem., 276, 6727-6738. Schlegel, A., Arvan, P., and M.P. Lisanti. 2001. Caveolin-1 binding to endoplasmic reticulum (ER) membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the ER. J. Biol. Chem., 276, 4398-4408. Liu, J., Lee, P., Galbiati, F., Kitsis, R.N., and M.P. Lisanti. 2001. Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation. Am. J. Physiol., 280, C823-C835. Rybin, V.O., Xu, X., Lisanti, M.P., and S.F. Steinberg. 2000. Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae: A mechanism to functionally regulate the cAMP signaling pathway. J. Biol. Chem., 275: 41447-41457. Razani, B., Altschuler, Y., Zhu, L., Pestell, R.G., Mostov, K.E., and M. P. Lisanti. 2000. Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus (HPV), in a p53-dependent manner: Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochemistry, 39, 13916-13924. Sotgia, F., Lee, J.K., Das, K., Bedford, M., , Petrucci, T.C., Macioce, P., Sargiacomo, M., Bricarelli, F.D., Minetti, C., Sudol, M., and M.P. Lisanti. 2000. Caveolin-3 directly interacts with the C-terminal tail of ?-dystroglycan: Identification of a central WW-like domain within caveolin family members. J. Biol. Chem., 275, 38048-38058. Galbiati, F., Volonte', D., Minetti, C., Bregman, D.B., and M. P. Lisanti. 2000. Limb-girdle muscular dystrophy (LGMD-1C) mutants of caveolin-3 undergo ubiquitination and proteasomal degradation: Treatment with proteasomal inhibitors blocks the dominant negative effect of LGMD-1C mutants and rescues wild-type caveolin-3. J. Biol. Chem., 275, 37702-37711. Lee, H., Volonte', D., Galbiati, F., Iyengar, P., Lublin, D.M., Bregman, D.B., Wilson, M.T., Campos-Gonzalez, R., Bouzahzah, B., Pestell, R.G., Scherer, P.E., , and M. P. Lisanti. 2000. Constitutive and growth-factor regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: Identification of a c-Src/ Cav-1/ Grb-7 signaling cassette. Molec. Endocrinol. 14, 1750-1775. D'Amico, M., Hulit, J., Amanatullah, D.F., Zafonte, B.T., Albanese, C. Bouzahzah, B., Fu, M., Augenlicht, L.H., Donehower, L.A., Takemaru, K., Moon, R.T., Davis, R., Lisanti, M.P., Shtutman, M., Zhurinsky, J., Ben-Ze'ev, A., Troussard, A.A., Dedhar, S., and R.G. Pestell. 2000. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase-3? and CREB-dependent pathways. J. Biol. Chem., 275, 32649-32657. Engelman, J.A., Berg, A.H., Lewis, R.Y., Lisanti, M.P. and P.E. Scherer. 2000. TNFalpha-Mediated Insulin Resistance, but not De-Differentiation, is Abrogated by MEK1/2 Inhibitors in 3T3-L1 Adipocytes. Molec. Endocrinol. 14, 1557-1569. Galbiati, F., Volonte', D., Chu, J.B., Li, M., Fine, S.W., Fu, M., Bermudez, J., Pedemonte, M., Weidenheim, K.M., Pestell, R.G., Minetti, C., and M. P. Lisanti. 2000. Transgenic over-expression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype. Proc. Natl. Acad. Sci., USA, 97, 9689-9694. Huang, H., Petkova, S.B., Pestell, R.G., Bouzahzah, B., Chan, J., Magazine, H., Weis, L.M., Christ, G.J., Lisanti, M.P., Douglas, S.A., Shtutin, V., Halonen, S.K., Wittner, M., and H.B. Tanowitz. 2000. Trypanosoma cruzi infection (Chagas' Disease) of mice causes activation of the MAP kinase cascade and expression of endothelin-1 (ET-1) in the myocardium. J. Cardiovasc. Pharmacol. 36 (Suppl.1), S148-S150. Lin, Y., Lee, H., Berg, A.H., Lisanti, M.P., Shapiro, L., and P.E. Scherer. 2000. LPS activated TLR-4 receptor induces synthesis of the closely related receptor TLR-2 in adipocytes. J. Biol. Chem.,275, 24255-24263. Galbiati, F., Volonte', D., Brown, A.M.C., Weinstein, D.E., Ben-Ze'ev, A., Pestell, R.G., and M. P. Lisanti. 2000. Caveolin-1 expression inhibits Wnt/ ?-catenin/Lef-1 signaling by recruiting ?-catenin to caveolae membrane domains. J. Biol. Chem., 275, 23368-23377. Schlegel, A., and M.P. Lisanti. 2000. A molecular dissection of caveolin-1 membrane attachment and oligomerization: Two separate regions of the caveolin-1 C-terminal domain mediate membrane binding and oligomer/oligomer interactions in vivo. J. Biol. Chem., 275, 21605-21617. Hulit, J., Bash, T., Fu, M., Galbiati, F., Albanese, C., Sage, D.R., Schlegel, A., Zhurinsky, J., Shtutman, M., Ben-Ze'ev, A., Lisanti, M.P., and R.G. Pestell. 2000. The cyclin D1 gene is transcriptionally repressed by caveolin-1. J. Biol. Chem., 275, 21203-21209. Zhang, W., Razani, B., Altschuler, Y., Bouzahzah, B., Mostov, K.E., Pestell, R.G., and M. P. Lisanti. 2000. Caveolin-1 inhibits EGF-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenoviral-mediated gene delivery of caveolin-1. J. Biol. Chem., 275, 20717-207125. Park, H., Go, Y.-M., Darji, R., Choi, J.-W., Lisanti, M.P., Maland, M.C., and H. Jo. 2000. Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase (ERK). Am. J. of Physiol. (Heart and Circ. Physiol.), 278: H1285-H1293. Carbone, I., Bruno, C., Sotgia, F. , Bado, M., Broda, P, Masetti, E., Panella, A., Zara, F., Dagna Bricarelli, F., Cordone, G., Lisanti, M.P., and C. Minetti. 2000. Mutation in the CAV3 gene causes partial caveolin-3 deficiency and hyperCKemia. Neurology, 54, 1373-1376. Engelman, J.A., Berg A., Lewis, R., Lin, A., Lisanti, M.P., and P.E. Scherer. 1999. Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis. J. Biol. 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Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts. Transient activation of p38 MAP kinase is required for induction of caveolin-3 expression and subsequent myotube formation. J. Biol. Chem., 274, 30315-30321. Bàthori, G., Parolini, I., Tombola, F., Szabò, I., Messina, A., Oliva, M., De Pinto, V., Lisanti, M. P., Sargiacomo, M., and M. Zoratti. 1999. Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. J. Biol. Chem., 274, 29607-29612. Mora, R., Bonilha, V., Marmostein, A., Scherer, P.E., Brown, D., Lisanti, M.P., and E. Rodriguez-Boulan. 1999. Caveolin-2 localizes to the Golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J. Biol. Chem., 274, 25708- 25717. Razani, B., Rubin, C.S., and M. P. Lisanti. 1999. Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A. J. Biol. Chem., 274, 26353-26360. Galbiati, F., Volonte', D., Minetti, C., Chu, J.B., and M.P. Lisanti.1999. Phenotypic behavior of caveolin-3 mutations that cause autosomal dominant limb girdle muscular dystrophy (LGMD-1C). Retention of LGMD-1C caveolin-3 mutants within the Golgi complex. J. Biol. Chem., 274, 25632-25641. Parolini, I., Sargiacomo, M., Galbiati, F., Rizzo, G., Grignani, F., Engelman , J.A., Okamoto, T., Ikezu, T., Scherer, P.E., Mora, R., Rodriguez-Boulan, E., Peschle, C., and M.P. Lisanti. 1999. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the Golgi complex. J. Biol. Chem., 274, 25718-25725. Repetto, S., Bado, M., Broda, P., Lucania, G., Masetti, E., Sotgia, F., Carbone, I., Pavan, A., Bonilla, E., Cordone, G., Lisanti, M.P., and C. Minetti. 1999. Increased number of caveolae and caveolin-3 over-expression in Duchenne muscular dystrophy. Biochem. Biophys. Res. Com. (BBRC)., 261, 547-550. Schlegel, A., Schwab, R.B., Scherer, P.E., and M.P. Lisanti. 1999. A role for the caveolin-scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin-scaffolding domain is both necessary and sufficient for membrane binding in vitro. J. Biol. Chem., 274, 22660-22667. Sotgia F, Minetti C, and M.P. Lisanti. 1999. Localization of the human caveolin-3 gene to the D3S18/D3S4163/ D3S4539 locus (3p25), in close proximity to the human oxytocin receptor gene. Identification of the caveolin-3 gene as a candidate for deletion in 3p- syndrome., FEBS Lett., 452, 177-180. Nishiyama, K., Trapp, B.D., Ikezu, T., Ransohoff, R.M., Tomita, T.,Iwatsubo, T., Kanazawa, I., Hsiao, K.K., Lisanti, M.P., and T. Okamoto. 1999. Caveolin-3 up-regulation activates ?-secretase mediated cleavage of the amyloid precursor protein (APP) in Alzheimer's disease. J. Neuroscience., 19, 6538-6548. Das, K., Lewis, R.Y., Scherer, P.E., and M.P. Lisanti. 1999. The membrane spanning domains of caveolins 1 and 2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J. Biol. Chem., 274, 18721-18726. Schwab, W., Galbiati, F., Volonte', D., Hempe, U., Wenzel, K.W., Funk, R. H.W., Lisanti, M.P., and M. Kasper. 1999. Characterization of caveolins from the cartilage: Differential expression of caveolin-1,-2 and -3 in chondrocytes and in alginate cell culture ofthe rat tibia. Histochem. Cell Biol., 112, 41-49. Liu, J., Razani, B., Tang, S., Terman, B.I., Ware, J.A., and M. P. Lisanti. 1999. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block VEGF-induced down-regulation of caveolin-1. J. Biol. Chem., 274, 15781-15785. Engelman, J.A., Zhang, X.L., and M. P. Lisanti. 1999. Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. FEBS Lett., 448, 221-230. Parolini, I., Topa, S., Sorice, M., Pace, A., Ceddia, P., Montesoro, E., Pavan, A., Lisanti, M.P., Peschle, C., and M. Sargiacomo. 1999. Phorbol-ester-induced disruption of the CD4/Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated PKC isoforms. J. Biol. Chem., 274, 14176- 14187. Volonte', D., Galbiati, F., Li, S., Nishiyama, K., Okamoto, T., and M.P. Lisanti. 1999. Flotillins/ Cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. J. Biol. Chem., 274, 12702-12709. Carman, C.V., Lisanti, M.P., and J.L. Benovic. 1999. Regulation of G protein-coupled receptor kinases (GRKs) by caveolin. J. Biol. Chem., 274, 8858-8864. Volonte', D., Galbiati, F., and M.P. Lisanti. 1999. Visualization of caveolin-1, a caveolar marker protein, in living cells using green fluorescent protein (GFP) chimeras. The subcellular distribution of caveolin-1 is modulated by cell-cell contact. FEBS Lett., 445, 431-439. Galbiati, F., Volonte', D., Meani, D., Milligan, G. , Lublin, D.M., Lisanti, M.P. and M. Parenti. 1999. The dually acylated N-terminal domain of Gi1? is sufficient to target a GFP reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated G-protein ?-subunits in vivo . J. Biol. Chem., 274, 5843-5850. Bilderback, T.R., Gazula, V.R., , Lisanti, M.P., and R.T. Dobrowsky. 1999. Caveolin interacts with Trk A and p75NTR and regulates neurotrophin signaling pathways. J. Biol. Chem., 274, 257-263. Yang, C.-P., Galbiati, F., Volonte', D., Horwitz, S.B., and M.P. Lisanti. 1998. Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS Lett., 439, 368-372. Engelman, J.A., Zhang, X.L., and M. P. Lisanti. 1998. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Lett., 436, 403-410. Galbiati, F., Volonte', D., Engelman, J.A., Watanabe, G., Burk, R., Pestell, R.G., and M. P. Lisanti. 1998. Targeted down-regulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J., 17, 6633-6648. Engelman, J.A., Lisanti, M.P., and Scherer, P.E. 1998. Specific inhibitors of p38 MAP kinase block 3T3-L1 adipogenesis. J. Biol. Chem., 273, 32111-32120. Park, H., Go, Y-M., St. John, P.L., Maland, M.C., Lisanti, M.P., Abrahamson, D.R., and H. Jo. 1998. Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase (ERK). J. Biol. Chem., 273, 32304-32311. Li, S., Galbiati, F., Volonte, D. , Sargiacomo, M., Engelman, J.A., Das, K., Scherer, P.E., and M.P. Lisanti. 1998. Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes. FEBS Lett., 434, 127-134. Yamamoto, M., Toya, Y., Schwencke, C., Lisanti, M.P., Myers, M., and Y. Ishikawa. 1998. Caveolin is an activator of insulin receptor signaling. J. Biol. Chem., 273, 26962- 26968. Galbiati, F., Volonte', D., Gil, O., Zanazzi, G., Salzer, J.L., Sargiacomo, M., Scherer, P.E., Engelman, J.A., Schlegel, A., Parenti, M., Okamoto, T., and M.P. Lisanti. 1998. Expression of caveolin-1 and-2 in differentiating PC12 cells and dorsal root ganglion neurons: Caveolin-2 is upregulated in response to cell injury. Proc. Natl. Acad. Sci., USA, 95, 10257-10262. Ghosh, S., Gachhui, R., Crooks, C., Wu, C., Lisanti, M.P., and D.J. Stuehr. 1998. Interaction between caveolin-1 and the reductase domain of endothelial nitric oxide synthase: Consequences for catalysis. J. Biol. Chem., 273, 22267-22304. Engelman, J.A., Zhang, X.L., Galbiati, F., and M. P. Lisanti. 1998. Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/ 7q31). FEBS Lett., 429, 330-336. Engelman, J.A., Chu, C., Lin, A., Jo, H., Ikezu, T., Okamoto, T., Kohtz, D.S., and M.P. Lisanti. 1998. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett., 428, 205-211. Engelman, J.A., Lee, R.J., Karnezis, A., Bearss, D.J., Webster, M. , Siegel, P. Muller, W.J., Windle, J.J. , Pestell, R.G., and M. P. Lisanti. 1998. Reciprocal regulation of Neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J. Biol. Chem., 273, 20448-20455. Ikezu , T., Ueda, H., Trapp, B.D., Nishiyama, K., Sha, J.F., Volonte, D., Galbiati, F., Byrd, A.L., Bassell, G., Serizawa, H., Lane, W.S., Lisanti, M. P., and T. Okamoto. 1998. Affinity-purification and characterization of caveolins from the brain. Differential expression of caveolin-1, -2 and -3 in brain endothelial and astroglial cell types. Brain Res., 804, 177-192. Crosbie, R.H., Yamada, H., Venzke, D.P., Lisanti, M.P., and K.P. Campbell. 1998. Caveolin-3 is not an integral component of the dystrophin glycoprotein complex. FEBS Lett., 427, 279-282. Ikezu, T., Trapp, B.D., Song, K.S., Schegel, A., Lisanti, M.P., and T. Okamoto. 1998. Caveolae, plasma membrane micro-domains for ?-secretase-mediated processing of the amyloid precursor protein (APP). J. Biol. Chem., 273, 10485-10495. Minetti, C., Sotgia, F., Bruno, C., Scartezzini, P., Broda, P., Bado, M., Masetti, E., Mazzocco, P., Egeo, A., Donati, M.A., Volonte', D., Galbiati, F., Cordone, G., Bricarelli, F.D., Lisanti, M.P., and F. Zara. 1998. Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy. Nature Genetics., 18: 365-368. McNally,E.M., de Sá Moreira, E., Duggan, D.J., Bönnemann, C.G., Lisanti, M.P., Lidov, H.G.W., Vainzof, M., Passos-Bueno, M.R., Hoffman, E.P., Zatz, M. and L.M. Kunkel. 1998. Caveolin-3 in muscular dystrophy. Human Molecular Genetics, 7: 871-877. Galbiati, F., Volonte ', D., Goltz, J.S., Steele, Z., Sen, J., Jurcsak, J., Stein, D., Stevens, L., and M. P. Lisanti. 1998. Identification, sequence, and develop-mental expression of invertebrate Flotillins from Drosophila melanogaster. Gene., 210: 229-237. Toya, Y., Schwencke, C., Couet, J., Lisanti, M.P., and Y. Ishikawa. 1998. Inhibition of adenyl cyclase by caveolin peptides. Endocrinology, 139: 2025-2031. Breton, S. , Lisanti, M.P., Tyszkowski, R., McLaughlin, M., and D. Brown. 1998. Distribution of caveolin-1 in the kidney: Absence from H+-ATPase-coated endocytic vesicles in intercalated cells. J. Histochem. Cytochem., 46: 205-214. Oka, N., Yamamoto, M., Schwencke, C., Kawabe, J., Ebina, T., Couet, J., Lisanti, M.P., and Y. Ishikawa. 1997. Caveolin interaction with protein kinase C: Isoenzyme-dependent regulation of kinase activity by the caveolin-scaffolding domain peptide. J. Biol. Chem., 272, 33416-33421. Couet, J., Sargiacomo, M. and M. P. Lisanti. 1997. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins: Caveolin-binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem., 272, 30429-30438. Scherer, P.E., Lewis, R.Y., Volonte, D., Engelman, J.A., Galbiati, F., Couet, J., Kohtz, D.S., van Donselaar, E., Peters, P. and M. P. Lisanti. 1997. Cell-type and tissue-specific expression of caveolin-2: Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J. Biol. Chem., 272, 29337-29346. Garcia-Cardena, G., Martasek, P., Siler-Masters, B.S., Skidd, P.M., Couet, J.C., Li, S., Lisanti, M.P., and Sessa, W.C. 1997. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: Functional Significance of the NOS caveolin binding domain in vivo. J. Biol. Chem. (Communication), 272: 25437-25440. Kübler, E., Mösch, H.-U., Rupp, S. and M. P. Lisanti. 1997. Gpa2p, a G-protein ?-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J. Biol. Chem.(Communication), 272: 20321-20323. Scherer, P.E., and M.P. Lisanti. 1997. Association of phosphofructokinase-M with caveolin-3 in differentiated skeletal myotubes: Dynamic regulation by extracellular glucose and intracellular metabolites. J. Biol. Chem., 272: 20698-20705. Engelman, J.A., Wykoff, C.C., Yasuhara, S., Song, K.S., Okamoto, T., and M.P. Lisanti. 1997. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J. Biol. Chem., 272: 16374-16381. Puertollano, R., Li, S., Lisanti, M.P., and M.A. Alonso. 1997. Recombinant expression of the MAL proteolipid, a component of glycolipid-enriched membrane microdomains, induces the formation of vesicular structures in insect cells. J. Biol. Chem., 272: 18311-18357. Bickel, P.E., Scherer, P.S., Schnitzer, J.E., Oh, P., Lisanti, M.P., and H.F. Lodish. 1997. Flotillin and ESA define a new family of caveolae-associated integral membrane proteins. J. Biol. Chem., 272: 13793-13815. Song K.S., Sargiacomo M., Galbiati F., Parenti M., and M.P. Lisanti. 1997. Targeting of a G alpha subunit (Gi1 alpha) and c-Src tyrosine kinase to caveolae membranes: Clarifying the role of N-myristoylation. Cell. Mol. Biol. (Noisy-Le-Grand) 43: 293-303. Couet, J., Li, S., Okamoto, T., Ikezu, T., and M.P. Lisanti. 1997. Identification of peptide and protein ligands for the caveolin-scaffolding domain (CSD). Implications for the interaction of caveolin with caveolin-associated proteins. J. Biol. Chem., 272: 6525-6533. Song,K.S.,Tang, Z.-L., Li, S., and M.P. Lisanti. 1997. Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions. J. Biol. Chem., 272: 4398-4403. Tang, Z.-L., Okamoto, Boontrakulpoontawee, P., Katada, T., Otsuka, T., and M.P. Lisanti. 1997. Identification, sequence and expression of an invertebrate caveolin gene family from the nematode C. elegans. Implications for the molecular evolution of mammalian caveolin genes. J. Biol. Chem., 272: 2437-2445. Eric Kübler, Henrik G. Dohlman, and M. P. Lisanti. 1996. Identification of Triton X-100 insoluble membrane domains in the yeast Saccharomyces cerevisiae. Lipid requirements for targeting of hetero-trimeric G protein subunits. J. Biol. Chem., 271: 32975-32980. Li, S., Song,K.S., Koh, S.S., Kikuchi, A. and M. P. Lisanti. 1996. Baculovirus-based expression of mammalian caveolin in Sf21 insect cells. A model system for the biochemical and morphological study of caveolar biogenesis. J. Biol. Chem., 271: 28647-28654. Li, S., Couet, J., and M. P. Lisanti. 1996. Src-tyrosine kinases, G alpha subunits and H-Ras share a common membrane-anchored scaffolding protein, Caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J. Biol. Chem., 271: 29182-29190. Song, K.S., Scherer, P.E., Tang, Z-L., Okamoto, T., Li, S., Chafel, M., Chu, C., Kohtz, D.S., and M. P. Lisanti. 1996. Expression of caveolin-3 in skeletal, cardiac and smooth muscle cells: Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J. Biol. Chem., 271: 15160-15165. Song, K.S., Li, S., Okamoto, T., Quilliam, L.A., Sargiacomo, M., and M. P. Lisanti. 1996. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae membranes. J. Biol. Chem., 271: 9690-9697. Li, S., Seitz, R., and M. P. Lisanti. 1996. Phosphorylation of caveolin by Src tyrosine kinases: The ?-isoform of caveolin is selectively phosphorylated by v-Src in vivo. J. Biol. Chem., 271: 3863-3868. Parolini, I., Sargiacomo, M., Lisanti, M. P., and C. Peschle. 1996. Signal transduction and GPI-linked proteins (Lyn, Lck, CD4, CD45, G proteins, CD 55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes. Blood, 87: 3783-3794. Tang, Z.-L., Scherer, P.E., Okamoto, T., Song, K., Chu, C., Kohtz, D.S., Nishimoto, I., Lodish, H.F. and M.P. Lisanti. 1996. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J. Biol. Chem., 271: 2255-2261. Scherer, P.E., Okamoto, T., Chun, M., Nishimoto, I., Lodish, H.F. and M.P. Lisanti 1996. Identification, sequence and expression of caveolin-2 defines a caveolin gene family. Proc. Natl. Acad. Sci., USA, 93: 131-135. Li, S., Song, K.S and M. P. Lisanti. 1996. Expression and characterization of recombinant caveolin: Purification by poly-histidine tagging and cholesterol-dependent incorporation into defined lipid membranes. J. Biol. Chem., 271, 568-573. Koleske, A.J., Baltimore, D., and M. P. Lisanti. 1995. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc. Natl. Acad. Sci., USA, 92: 1381-1385. Li, S., Okamoto, T., Chun, M., Sargiacomo, M., Casanova, J. E., Nishimoto, I. and M. P. Lisanti. 1995. Evidence for a regulated interaction between hetero-trimeric G proteins and caveolin. J. Biol. Chem., 270: 15693-15701. Scherer, P.S., Tang, Z.-L., Chun, M., Sargiacomo, M., Lodish, H.F. and M.P. Lisanti. 1995. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution: Identification and epitope mapping of an isoform-specific monoclonal antibody probe. J. Biol. Chem., 270: 16395-16401. Sargiacomo, M., Scherer, P.E., Tang, Z.-L., Kubler, E., Song, K., Sanders, M., and M. P. Lisanti. 1995. Oligomeric structure of caveolin: Implications for caveolae membrane organization. Proc. Natl. Acad. Sci., USA, 92: 9407-9411. Kuliawat, R., Lisanti, M.P., and P. Arvan. 1995. Polarized distribution and delivery of plasma membrane proteins in thyroid follicular epithelial cells. J. Biol. Chem., 270: 2478-2482. Lisanti, M.P., Scherer, P.E., Vidugiriene, J., Tang, Z.-L., Vosatka, A. H-. Tu, Y-H., Cook, R.F., and M. Sargiacomo. 1994. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implications for human disease. J. Cell Biol., 126: 111-126. Tang, Z.-L., Scherer, P.E., and M. P. Lisanti. 1994. The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene 147: 299-300. Sargiacomo, M., Scherer, P.E., Tang, Z.-L., Casanova, J.E., and M. P. Lisanti. 1994. In vitro phosphorylation of caveolin-rich membrane domains: Identification of an associated serine kinase activity as a casein kinase II-like enzyme. Oncogene 9: 2589 -2595. Chun, M., Liyanage, U.K., Lisanti, M.P., and H. F. Lodish. 1994. Signal transduction of a G-protein coupled receptor in caveolae: Colocalization of endothelin and its receptor with caveolin. Proc. Natl. Acad. Sci., USA, 91: 11728-11732. Scherer, P., Lisanti, M.P., Baldini, G., Sargiacomo, M. and H. F. Lodish. 1994. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J. Cell Biol., 127: 1233-1243. Lisanti, M.P., Tang, Z.-L., and M. Sargiacomo. 1993. Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: Implications for the biogenesis of caveolae. J. Cell Biol., 123: 595-604. Sargiacomo, M., Sudol, M., Tang, Z.-L., and M. P. Lisanti. 1993. Signal transducing molecules and GPI-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J. Cell Biol., 122: 789-807. Zurzolo, C., Lisanti, M.P., Caras, I.W., Nitsch, L., and E. Rodriguez-Boulan. 1993. GPI anchored proteins are preferentially targeted to the basolateral surface in Fischer rat thyroid eptithelial cells. J. Cell Biol., 121: 1031-1039. Hannan, L.A., Lisanti, M.P., Rodriguez-Boulan, E., and M. Edidin. 1993. Correctly-sorted molecules of a GPI-anchored protein are clustered and immobile when they arrive at the apical surface of MDCK cells. J.Cell Biol. 120:353-358. Rosen, C.L., Lisanti, M.P., and J.L. Salzer. 1992. Expression of unique sets of GPI-anchored proteins by different primary neurons in vitro. J. Cell Biol., 117: 617-627. Lisanti, M.P., Field, M.C., Caras, I.W., Menon, A.K., and E. Rodriguez-Boulan. 1991. Mannosamine, a novel inhibitor of glycosyl-phosphatidylinositol incorporation into proteins., EMBO J., 10: 1969-1977. Lisanti, M.P., Caras, I.W., and E. Rodriguez-Boulan. 1991. Fusion proteins containing a minimal GPI-attachment signal are apically expressed in transfected MDCK cells. J. Cell Sci., 99: 637-640. Powell, S.K., Lisanti, M.P., and E. Rodriguez-Boulan. 1991. Thy-1 expresses two signals for apical localization in epithelial cells. Am. J. Physiol., 260: C715-C720. Lisanti, M.P., Caras, I.W., Gilbert, T., Hanzel, D., and E. Rodriguez-Boulan. 1990. Vectorial apical delivery and slow endocytosis of a glycolipid-anchored fusion protein in transfected MDCK cells. Proc. Natl. Acad. Sci. USA. 87: 7419-7423. Lisanti, M.P., Le Bivic, A., Saltiel, A.R. and E. Rodriguez-Boulan. 1990. Prefered apical distribution of glycosyl-phosphatidylinositol (GPI) anchored proteins: a highly conserved feature of the polarized epithelial cell phenotype J. Membr. Biol. 113: 155-167. Lisanti, M.P., Caras, I.W., Davitz, M.A. and E. Rodriguez-Boulan. 1989. A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells. J. Cell Biol. 109: 2145-2156. Lisanti, M.P., Le Bivic, A., Sargiacomo, M., and E. Rodriguez-Boulan. 1989 Steady-state distribution and biogenesis of endogenous MDCK glycoproteins: evidence for intracellular sorting and polarized cell surface delivery. J. Cell Biol. 109: 2117-2127. Lisanti, M.P., Darnell, J.C., Chan, B.L., Rodriguez-Boulan, E., and A.R. Saltiel. 1989. The distribution of glycosyl-phosphatidylinositol anchored proteins is differentially regulated by serum and insulin. Biochem. Biophys. Res. Commun. 164: 824-832. Sargiacomo, M., Lisanti, M.P., Graeve, L., LeBivic, A. and E. Rodriguez-Boulan. 1989. Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells. J. Membr. Biol. 107:277-286. Lisanti, M.P., Sargiacomo, M., Graeve, L., Saltiel, A.R. and E. Rodriguez-Boulan. 1988. Polarized apical distribution of glycosyl-phosphatidylinositol anchored proteins in a renal epithelial cell line. Proc. Natl. Acad. Sci. USA. 85:9557-9561. Chan, B.L., Lisanti, M.P., Rodriguez-Boulan, E. and A.R. Saltiel. 1988. Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor. Science (Wash., D.C.) 241:1670-1672. Lisanti, M.P., and S. Puszkin. 1985. Mathematical modeling of the formation of coated vesicles: A theoretical, geometrical approach. Biochem. J. 230:411-421. Lisanti, M.P., Flanagan, M., and S. Puszkin. 1984. Clathrin lattice reorganization: Theoretical considerations. J. Theor. Biol. 108: 143-157. Lisanti, M.P., Andres, A., Puszkin, A., Ores, C., Schook, W., and S. Puszkin 1983. Immunocytochemical characterization of clathrin-associated proteins: II. Immunolocalization of CAPs using selectively-absorbed IgG solutions. Cell Tiss. Res. 231: 507-518. Puszkin, S., Andres, A., Ores,C., Lisanti, M.P., and W. Schook. 1983. Immunocytochemical characterization of clathrin-associated proteins: I. Neuronal distribution of clathrin-associated proteins (CAPs), components of clathrin-coated vesicles. Cell Tiss. Res. 231: 495-505. Lisanti, M.P., Shapiro, L., Moskowitz, N., Hua, E., Puszkin, S., and W. Schook. 1982. Isolation and preliminary characterization of clathrin-associated proteins. Eur. J. Biochem. 125: 463-470. Lisanti, M.P., Schook, W., Moskowitz, N., Ores, C., and S. Puszkin. 1982. Brain clathrin and clathrin-associated proteins. Biochem. J. 201: 297-304. Lisanti, M.P., Schook, W., Moskowitz, N., Beckenstein, K., Bloom, W., and S. Puszkin. 1982. Brain clathrin: Studies of it ultrastructural assemblies. Eur. J. Biochem. 121: 617-622. Puszkin, S., Lisanti, M.P., Haver, K., Hua, E., Moskowitz, N., Bloom, W., and W. Schook. 1982. Brain clathrin complex: II. Immunofluorescent correlation and biochemical affinity for actin. J. Histochem. Cytochem. 30: 497-503 Moskowitz, N., Schook, W., Lisanti, M.P., Hua, E., and S. Puszkin. 1982. Calmodulin affinity for brain coated vesicle proteins. J. Neurochem. 38: 1742-1747.